Why peptoids
A peptide-like backbone — without the peptide’s liabilities.
Peptoids replace the peptide's α-carbon side chain with a tertiary amine on nitrogen. The result is a backbone that is proteolytically stable, easy to diversify, and chemically scalable.
What they are
N-substituted glycines.
Peptoids are oligomers of N-substituted glycines (NSGs). Where a peptide carries its side chain on the α-carbon, a peptoid carries it on the amide nitrogen.
The change collapses chirality at the backbone, eliminates the amide N–H, and removes the substrate recognition that proteases require.
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